FGF1

Gene FGF1 map

Identifiers
fibroblast growth factor 1 (acidic)
HUGO:FGF1 HGNC:3665 ENTREZ:2246 UNIPROT:P05230 GENECARDS:FGF1 REACTOME:54762 KEGG:2246 ATLASONC:GC_FGF1 WIKI:FGF1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.


Modifications:
In compartment: Nucleus
  1. gFGF1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gFGF1@Nucleus map map rFGF1@Nucleus map

    As Catalyser:

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