Fe2+:PHD*

Complex Fe2+:PHD* map


Complex composition:

  1. PHD* map
  2. Fe2+ map




Fe2+:​PHD*@Cytoplasm

Identifiers
NAME:Fe2+:PHD*

References
a_re393:( Apoptosis  map ) PMID:12702559
a_re387( Apoptosis  map ):
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation
a_re392( Apoptosis  map ):
PMID:15369676
inhibition of PHD by ROS
PMID:20675386
questions the hypothesis of mitochondrial derived ROS inhibiting directly PHD upon hypoxia
proposes HIF1A stabilization upon respiratory chain inhibition would rather result from enhanced oxygen availability

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. Fe2+:​PHD*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. Fe2+:​PHD*@Cytoplasm map + ROS@Cytoplasm map map Fe3+:​PHD*@Cytoplasm map

  2. Fe3+:​PHD*@Cytoplasm map + L-ascorbate@Cytoplasm map map Fe2+:​PHD*@Cytoplasm map
  3. PHD*@Cytoplasm map map Fe2+:​PHD*@Cytoplasm map

As Catalyser:

  1. HIF1A@Cytoplasm map + O_sub_2_endsub_@Cytoplasm map + 2-oxoglutarate@Cytoplasm map map HIF1A|​P564_hyd@Cytoplasm map + succinate@Cytoplasm map + CO_sub_2_endsub_@Cytoplasm map

Leave a Reply