FANCM

Protein FANCM map

Identifiers
Fanconi anemia, complementation group M
HUGO:FANCM HGNC:23168 ENTREZ:57697 UNIPROT:Q8IYD8 GENECARDS:FANCM REACTOME:229316 KEGG:57697 ATLASONC:GC_FANCM WIKI:FANCM

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / FANCONI  map
 DNA repair  map  / NER  map
 DNA repair  map  / TLS  map

References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773
FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex
PMID:19622404
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase
PMID:19282663, PMID:19622404
Link between Fanconi and NER
PMID:22615860
Fanconi and cross-linking agents
PMID:21948210
FA core complex regulates REV1 and activated TLS
PMID:22266823

FANCM|​pho@default

References
d_re194( DNA repair  map ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
d_re195( DNA repair  map ):
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156

FANCM@default

References
d_re14( DNA repair  map ):
Link between Fanconi and NER
PMID:22615860
d_re194( DNA repair  map ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
d_re199( DNA repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re252( DNA repair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011


Modifications:
In compartment: default
  1. FANCM@default map

  2. FANCM|​pho@default map

Participates in complexes:
In compartment: default

  1. FAAP24*:​FANCM@default map

  2. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

Participates in reactions:
As Reactant or Product:

  1. FAAP24*@default map + FANCM@default map map FAAP24*:​FANCM@default map

  2. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. FANCM@default map map FANCM|​pho@default map
  4. FANCM|​pho@default map map degraded
  5. HCLK2*@default map + FAAP24*@default map + FANCM@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
  6. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

  2. G2 phase@default map map M phase@default map
  3. gTC-NER_DNA_st2*@Nucleus map map gTC-NER_GG-NER_DNA_st3*@Nucleus map
  4. gFanconi_DNA_st1*@Nucleus map map gFanconi_DNA_st2*@Nucleus map
  5. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  6. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  7. FANCI|​pho@default map map FANCI|​K523_ubi|​pho@default map
  8. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  9. FANCD2@default map map FANCD2|​pho@default map
  10. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  11. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
  12. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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