FANCL

Protein FANCL map

Identifiers
Fanconi anemia, complementation group L

Maps_Modules
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map

References
The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823

FANCL@default

References
d_re213( DNA repair  map ):
PMID:19264559
FANCL induces UBE2T auto-ubiquitination on Lys91 by this inactivating UBE2T. This is a negative loop:
PMID:16916645


Modifications:
In compartment: default
  1. FANCL@default map

Participates in complexes:
In compartment: default

  1. FAAP100*:​FANCB:​FANCL@default map

  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

Participates in reactions:
As Reactant or Product:

  1. FANCB@default map + FANCL@default map + FAAP100*@default map map FAAP100*:​FANCB:​FANCL@default map

  2. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

As Catalyser:

  1. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map

  2. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  3. FANCI|​pho@default map map FANCI|​K523_ubi|​pho@default map
  4. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  5. FANCD2@default map map FANCD2|​pho@default map
  6. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  7. UBE2T@default map map UBE2T|​k91_ubi@default map
  8. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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