FANCJ*:MLH1:PMS2

Complex FANCJ*:MLH1:PMS2 map


Complex composition:

  1. FANCJ* map
  2. PMS2 map
  3. MLH1 map




FANCJ*:​MLH1:​PMS2@default

Identifiers
NAME:FANCJ*:MLH1:PMS2

Maps_Modules
 DNA repair  map  / TLS  map
 DNA repair  map  / FANCONI  map

References
PMID:17581638
Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism
PMID:20173781
d_re250( DNA repair  map ):
Link between MMR and Fanconi:
d_re162( DNA repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: default
  1. FANCJ*:​MLH1:​PMS2@default map

Participates in reactions:
As Reactant or Product:

  1. FANCJ*@default map + MLH1:​PMS2@default map map FANCJ*:​MLH1:​PMS2@default map

As Catalyser:

  1. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map

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