FANCJ*

Protein FANCJ* map

Identifiers
BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ
HUGO:BRIP1 HGNC:20473 ENTREZ:83990 UNIPROT:Q9BX63 GENECARDS:BRIP1 REACTOME:229313 KEGG:83990 ATLASONC:GC_BRIP1 WIKI:BRIP1

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / TLS  map
 DNA repair  map  / FANCONI  map

References
PMID:19686080, PMID:19622404, PMID:18931676
Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism
PMID:20173781

FANCJ*|​S990_pho@default

References
d_re204:( DNA repair  map ) PMID:15242590

FANCJ*@default

References
d_re162( DNA repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
d_re250( DNA repair  map ):
Link between MMR and Fanconi:
PMID:17581638


Modifications:
In compartment: default
  1. FANCJ*@default map

  2. FANCJ*|​S990_pho@default map

Participates in complexes:
In compartment: default

  1. BRCA1:​FANCJ*|​S990_pho@default map

  2. FANCJ*:​MLH1:​PMS2@default map
  3. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  4. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

Participates in reactions:
As Reactant or Product:

  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

  2. FANCJ*|​S990_pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1:​FANCJ*|​S990_pho@default map
  3. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  4. FANCJ*@default map + MLH1:​PMS2@default map map FANCJ*:​MLH1:​PMS2@default map
  5. FANCJ*@default map map FANCJ*|​S990_pho@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

  2. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  3. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map
  4. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  6. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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