FANCD2

Protein FANCD2 map

Identifiers
Fanconi anemia, complementation group D2
HUGO:FANCD2 HGNC:3585 ENTREZ:2177 UNIPROT:Q9BXW9 GENECARDS:FANCD2 REACTOME:229217 KEGG:2177 ATLASONC:FAD WIKI:FANCD2

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / FANCONI  map

References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763

FANCD2|​S222_pho@default

References
d_re198( DNA repair  map ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re119( DNA repair  map ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767

FANCD2|​K561_ubi|​pho@default

References
d_re158( DNA repair  map ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151
d_re146( DNA repair  map ):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
d_re162( DNA repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
d_re206( DNA repair  map ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
PMID:14988723

FANCD2|​pho@default

References
d_re187( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re158( DNA repair  map ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151

FANCD2@default

References
d_re187( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re198( DNA repair  map ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603


Modifications:
In compartment: default
  1. FANCD2@default map

  2. FANCD2|​pho@default map
  3. FANCD2|​S222_pho@default map
  4. FANCD2|​K561_ubi|​pho@default map

Participates in complexes:
In compartment: default

  1. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map

  2. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​POLN@default map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  5. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  6. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  8. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

Participates in reactions:
As Reactant or Product:

  1. RAD51:​XRCC2:​XRCC3@default map + BARD1:​BRCA1@default map + RAD52@default map + BRCA2:​DSS1*@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho@default map + BRIT1*@default map + SFPQ@default map map BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

  2. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  3. FANCD2|​K561_ubi|​pho@default map + FANCI|​K523_ubi|​pho@default map map FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map
  4. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​pho|​ubi@default map + TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  5. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  6. FANCD2@default map map FANCD2|​pho@default map
  7. FANCD2|​K561_ubi|​pho@default map map FANCD2|​pho@default map
  8. FANCD2@default map map FANCD2|​S222_pho@default map
  9. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  10. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + POLN@default map map FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​POLN@default map
  11. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  12. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

As Catalyser:

  1. G1 phase@default map map S phase@default map

  2. S phase@default map map G2 phase@default map
  3. G2 phase@default map map M phase@default map
  4. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  5. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map
  6. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map
  7. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  8. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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