FANCA

Protein FANCA map

Identifiers
Fanconi anemia, complementation group A
HUGO:FANCA HGNC:3582 ENTREZ:2175 UNIPROT:O15360 GENECARDS:FANCA REACTOME:54632 KEGG:2175 ATLASONC:FA1ID102 WIKI:FANCA

Maps_Modules
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map

References
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823

FANCA|​pho@default

References
d_re186( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
d_re162( DNA repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404

FANCA@default

References
d_re525( DNA repair  map ):
HSP90 redirects FANCA to degradation, inhibits Fanconi pathway and increases sensitivity to cross-linking agents
PMID:17327415


Modifications:
In compartment: default
  1. FANCA@default map

  2. FANCA|​pho@default map

Participates in complexes:
In compartment: default

  1. FANCA|​pho:​FANCG|​S7_pho@default map

  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

Participates in reactions:
As Reactant or Product:

  1. FANCG|​S7_pho@default map + FANCA|​pho@default map map FANCA|​pho:​FANCG|​S7_pho@default map

  2. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. FANCA@default map map FANCA|​pho@default map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map
  5. FANCA@default map map FANCA@default map
  6. FANCA@default map map degraded

As Catalyser:

  1. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map

  2. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  3. FANCI|​pho@default map map FANCI|​K523_ubi|​pho@default map
  4. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  6. FANCD2@default map map FANCD2|​pho@default map
  7. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  8. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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