FAAP24*:FANCM

Complex FAAP24*:FANCM map


Complex composition:

  1. FAAP24* map
  2. FANCM map




FAAP24*:​FANCM@default

Identifiers
NAME:FAAP24*:FANCM

Maps_Modules
 DNA repair  map  / FANCONI  map

References
FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex, function is damage recognition
PMID:19622404
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. FAAP24*:​FANCM@default map

Participates in reactions:
As Reactant or Product:

  1. FAAP24*@default map + FANCM@default map map FAAP24*:​FANCM@default map

  2. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

  2. gFanconi_DNA_st1*@Nucleus map map gFanconi_DNA_st2*@Nucleus map

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