EXO1

Protein EXO1 map

Identifiers
exonuclease 1
HUGO:EXO1 HGNC:3511 ENTREZ:9156 UNIPROT:Q9UQ84 GENECARDS:EXO1 KEGG:9156 ATLASONC:GC_EXO1 WIKI:EXO1

Maps_Modules
 DNA repair  map  / MMR  map
 DNA repair  map  / A_NHEJ  map
 DNA repair  map  / HR  map

References
PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416

EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default

References
d_re71( DNA repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063

EXO1@default

References
d_re71( DNA repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737


Modifications:
In compartment: default
  1. EXO1@default map

  2. EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map

Participates in complexes:
In compartment: Nucleus

  1. BLM:​EXO1@Nucleus map

  2. EXO1:​PCNA:​RFC*:​RPA1:​RPA2:​RPA3:​hMutL*:​hMutS*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. d_s2743 + d_s834 + EXO1@default map + RPA1:​RPA2:​RPA3@default map + PCNA@default map + RFC*@Nucleus map map EXO1:​PCNA:​RFC*:​RPA1:​RPA2:​RPA3:​hMutL*:​hMutS*@Nucleus map

  2. EXO1@default map + BLM@Nucleus map map BLM:​EXO1@Nucleus map
  3. EXO1@default map map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map
  4. EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map map degraded

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. gSSA_DNA_st1*@Nucleus map map gSSA_DNA_st2*@Nucleus map
  4. gMMR_DNA_st2*@Nucleus map map gMMR_DNA_st3*@Nucleus map

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