ETS1

Gene ETS1 map

Identifiers
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
HUGO:ETS1 HGNC:3488 ENTREZ:2113 UNIPROT:P14921 GENECARDS:ETS1 KEGG:2113 ATLASONC:ETS1ID40502ch11q24 WIKI:ETS1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:16391805
Ets-1 is a transcription factor
Ets-1 involves in inducing MMP2 expression by EMT in human squamous carcinoma cells

gETS1@Nucleus

References
e_re353( EMT  map ):
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
VEGF induces Ets-1 expression in bovine retinal endothelial cells and its expression is PKC/ERK pathway-dependent.
Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases
PMID:12490555
Snail is able to induce the expression of Slug and all other neural crest markers (Zic5, FoxD3, Twist and Ets1)
PMID:16716598
PMID:11708773
Endothelin1 is target gene of HIF1
PMID:21041997
In cells induced to undergo EMT, TGFB also activates the expresion of ZEB1 and ZEB2 through upregulation of ETS1 expression, which then may cooperate with the bHLH transcription factor E47 (TCF3)
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)


Modifications:
In compartment: Nucleus
  1. gETS1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gETS1@Nucleus map map rETS1@Nucleus map

    As Catalyser:

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