ERK*:MEK*:SEF*

Complex ERK*:MEK*:SEF* map


Complex composition:

  1. SEF* map
  2. ERK* map
  3. MEK* map




ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​SEF*@Cytoplasm

Identifiers
NAME:ERK*:MEK*:SEF*

References
s_mpk1_re84( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked.
PMID:18775330 PMID:19565474
s_mpk1_re94( Survival  map ):
RSK2 is a well known ERK substrate in the cytoplasm and has been shown to undergo autophosphorylation after ERK phosphorylation.
RSKs interact with ERK and dissociate upon activation.
Results suggested that KSR1 was the scaffold utilised by ERK1/2 for activating cPLA2 but not RSK1.
PMID:15239952 PMID:15187187 PMID:19114553

Confidence
REF=3 FUNC=4

ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm

Identifiers
NAME:ERK*:MEK*:SEF*

References
s_mpk1_re58( Survival  map ):
Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins.
PMID:19565474
s_mpk1_re84( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked.
PMID:18775330 PMID:19565474
s_mpk1_re191( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=1 FUNC=4

ERK*:​MEK*:​SEF*@Golgi Apparatus

Identifiers
NAME:ERK*:MEK*:SEF*

References
s_mpk1_re57( Survival  map ):
Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins.
PMID:19565474

Confidence
REF=0 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map

  2. ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​SEF*@Cytoplasm map

In compartment: Golgi Apparatus

  1. ERK*:​MEK*:​SEF*@Golgi Apparatus map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map

  2. MEK*@Cytoplasm map + ERK*@Cytoplasm map + SEF*@Golgi Apparatus map map ERK*:​MEK*:​SEF*@Golgi Apparatus map
  3. ERK*:​MEK*:​SEF*@Golgi Apparatus map map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
  4. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map + ERK*|​pho|​pho@Cytoplasm map map ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​SEF*@Cytoplasm map

As Catalyser:

  1. RSK*@Cytoplasm map map RSK*|​pho@Cytoplasm map

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