ERK*:MEK*:_beta_-Arrestin2*

Complex ERK*:MEK*:_beta_-Arrestin2* map


Complex composition:

  1. _beta_-Arrestin2* map
  2. MEK* map
  3. ERK* map




ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes

Identifiers
NAME:ERK*:MEK*:_beta_-Arrestin2*

References
s_mpk1_re86( Survival  map ):
The internalised GPCR receptor will finally be recycled into the cell membrane or be sent to lysosome for degradation (not modelled).
PMID:19565474
s_mpk1_re87( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
Beta-ARRESTIN prevents the translocation of ERK into the nucleus thereby reducing phosphorylation of nuclear substrates and consequently MODULE:MAPK map -dependent gene expression.
PMID:18775330 PMID:19091303
s_mpk1_re192( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=1 FUNC=4

ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:ERK*:MEK*:_beta_-Arrestin2*

References
s_mpk1_re87( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
Beta-ARRESTIN prevents the translocation of ERK into the nucleus thereby reducing phosphorylation of nuclear substrates and consequently MODULE:MAPK map -dependent gene expression.
PMID:18775330 PMID:19091303
s_mpk1_re94( Survival  map ):
RSK2 is a well known ERK substrate in the cytoplasm and has been shown to undergo autophosphorylation after ERK phosphorylation.
RSKs interact with ERK and dissociate upon activation.
Results suggested that KSR1 was the scaffold utilised by ERK1/2 for activating cPLA2 but not RSK1.
PMID:15239952 PMID:15187187 PMID:19114553

Confidence
REF=3 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Cytoplasm map

In compartment: Early Endosomes

  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map

  2. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map map GPCR*:​GRK*@Early Endosomes map + ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + RAF1@Cytoplasm map
  3. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + ERK*|​pho|​pho@Cytoplasm map map ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Cytoplasm map

As Catalyser:

  1. RSK*@Cytoplasm map map RSK*|​pho@Cytoplasm map

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