ERK*:KSR1:MEK*

Complex ERK*:KSR1:MEK* map


Complex composition:

  1. KSR1 map
  2. MEK* map
  3. ERK* map




ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm

Identifiers
NAME:ERK*:KSR1:MEK*

References
s_mpk1_re81( Survival  map ):
Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf.
PMID:19541618
s_mpk1_re83( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
PMID:18775330
s_mpk1_re189( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=2 FUNC=4

ERK*|​pho|​pho|​hm2:​KSR1:​MEK*|​pho|​pho@Cytoplasm

Identifiers
NAME:ERK*:KSR1:MEK*

References
s_mpk1_re83( Survival  map ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
PMID:18775330
s_mpk1_re82( Survival  map ):
Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts.
MAPKs activate cPLA2 (PLA2G4A) by phosphorylation.
PMID:19114553 PMID:8381049

Confidence
REF=3 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map

  2. ERK*|​pho|​pho|​hm2:​KSR1:​MEK*|​pho|​pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map

  2. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  3. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + ERK*|​pho|​pho@Cytoplasm map map ERK*|​pho|​pho|​hm2:​KSR1:​MEK*|​pho|​pho@Cytoplasm map

As Catalyser:

  1. PLA2G4A@Cytoplasm map map PLA2G4A|​pho@Cytoplasm map

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