ERK*:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*

Complex ERK*:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS* map


Complex composition:

  1. GRB2 map
  2. SOS* map
  3. LAMTOR2 map
  4. MP1* map
  5. RAF1 map
  6. ERK* map
  7. MEK* map
  8. RTK* map
  9. RAS* map




ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes

Identifiers
NAME:ERK*:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*

References
s_mpk1_re22( Survival  map ):
Recruitment and phosphorylation of ERK1 on late endosomes.
PMID:17496910
s_mpk1_re36( Survival  map ):
Activation of ERK pathway caused the dissociation of the MP1/ERK1 complex.
MP1 constitutively binds MEK1 but releases ERK / MAPK  map after activation. This turnover could provide an amplification mechanism that translates low MEK activity into sustained ERK / MAPK  map activation in which MP1 continues to supply MEK1 with inactive ERK / MAPK  map for phosphorylation.
PMID:15547943 PMID:16227978
s_mpk1_re193( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=1 FUNC=4


Modifications:
Participates in complexes:
In compartment: Late Endosomes
  1. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map

  2. ERK*@Cytoplasm map + GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  3. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*|​pho|​pho@Cytoplasm map

As Catalyser:

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