ERK2*

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Protein ERK2* map

Identifiers
mitogen-activated protein kinase 1
HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1
PRKM1, PRKM2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK2 (phosphorylated) may encounter monomeric, inactive ERK2.
ERK2 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK2 phosphorylates the critical Tyr and Thr on ERK2, converting two ATP to ADP. Phosphorylation of ERK-2 activates its kinase activity.
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:21196257, PMID:21196179

ERK2*@Cytoplasm

References
e_re391( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.

ERK2*|​T_pho|​Y_pho|​active@Cytoplasm

References
e_re391( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
e_re395( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.

ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm

References
e_re395( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
e_re383( EMT  map ):
Negative feedback: MAPK1/ERK2 phosphorylates RAF1 on Ser 29, 43, 289, 296, 301, 642, generating an inactive kinase.
PIN1, a prolyl isomerase converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A.
e_re397( EMT  map ):
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

ERK2*@default

References
d_re376:( DNA repair  map ) PMID:18083840

ERK2*@Nucleus

References
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs

Modifications:
In compartment: Cytoplasm
  1. ERK2*@Cytoplasm map

  2. ERK2*|​T_pho|​Y_pho|​active@Cytoplasm map
  3. ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map

In compartment: Nucleus

  1. ERK2*@Nucleus map

In compartment: default

  1. ERK2*@default map

Participates in complexes:
In compartment: Nucleus

  1. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. ERK1_2*@Cytoplasm map → map ERK2*|​T_pho|​Y_pho|​active@Cytoplasm map

  2. ERK2*@Cytoplasm map → map ERK2*|​T_pho|​Y_pho|​active@Cytoplasm map
  3. ERK2*|​T_pho|​Y_pho|​active@Cytoplasm map → map ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map
  4. CNA*:​CNB*:​NFAT*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map → map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  5. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map → map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  6. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map → map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  7. MAPK pathway@Cytoplasm map → map ERK2*@Nucleus map
  8. ERK2*@Cytoplasm map → map MAPK pathway@Cytoplasm map

As Catalyser:

  1. MPS1*@default map → map MPS1*|​T676_pho@default map

  2. RAF1|​closed@Cytoplasm map + ATP@Cytoplasm map → map RAF1|​S_pho|​closed@Cytoplasm map + ADP@Cytoplasm map
  3. MKNK2@Cytoplasm map + ATP@Cytoplasm map → map MKNK2|​pho@Cytoplasm map + ADP@Cytoplasm map
  4. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map → map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  5. APC@Cytoplasm map → map APC|​pho@Cytoplasm map

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