Identifiers
mitogen-activated protein kinase 1
HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1
PRKM1, PRKM2
Maps_Modules
EMT / EMT_REGULATORS
Survival / WNT_NON_CANONICAL
References
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK2 (phosphorylated) may encounter monomeric, inactive ERK2.
ERK2 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK2 phosphorylates the critical Tyr and Thr on ERK2, converting two ATP to ADP. Phosphorylation of ERK-2 activates its kinase activity.
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:21196257, PMID:21196179
ERK2*@Cytoplasm
References
e_re391( EMT ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
ERK2*|T_pho|Y_pho|active@Cytoplasm
References
e_re391( EMT ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
e_re395( EMT ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
ERK2*|T_pho|Y_pho|hm2|active@Cytoplasm
References
e_re395( EMT ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
e_re383( EMT ):
Negative feedback: MAPK1/ERK2 phosphorylates RAF1 on Ser 29, 43, 289, 296, 301, 642, generating an inactive kinase.
PIN1, a prolyl isomerase converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A.
e_re397( EMT ):
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase
ERK2*@default
References
d_re376:( DNA repair ) PMID:18083840
ERK2*@Nucleus
References
s_wnc3_re31( Survival ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs
Modifications:
In compartment: Cytoplasm
In compartment: Nucleus
In compartment: default
Participates in complexes:
In compartment: Nucleus
Participates in reactions:
As Reactant or Product:
- ERK1_2*@Cytoplasm
→
ERK2*|T_pho|Y_pho|active@Cytoplasm
- ERK2*@Cytoplasm
→
ERK2*|T_pho|Y_pho|active@Cytoplasm
- ERK2*|T_pho|Y_pho|active@Cytoplasm
→
ERK2*|T_pho|Y_pho|hm2|active@Cytoplasm
- CNA*:CNB*:NFAT*@Nucleus
+ ERK2*@Nucleus
+ MEK1*@Nucleus
→
CNA*:CNB*:ERK2*:MEK1*:NFAT*@Nucleus
- CNA*:CNB*:ERK2*:MEK1*:NFAT*@Nucleus
→
CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
- CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus
+ JUN@Nucleus
+ FOS@Nucleus
→
AP-1_ARRE binding sites*:FOS:JUN:NFAT*@Nucleus
+ CNA*:CNB*@Nucleus
+ ERK2*@Nucleus
+ MEK1*@Nucleus
- MAPK pathway@Cytoplasm
→
ERK2*@Nucleus
- ERK2*@Cytoplasm
→
MAPK pathway@Cytoplasm
As Catalyser:
- MPS1*@default
→
MPS1*|T676_pho@default
- RAF1|closed@Cytoplasm
+ ATP@Cytoplasm
→
RAF1|S_pho|closed@Cytoplasm
+ ADP@Cytoplasm
- MKNK2@Cytoplasm
+ ATP@Cytoplasm
→
MKNK2|pho@Cytoplasm
+ ADP@Cytoplasm
- CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus
+ JUN@Nucleus
+ FOS@Nucleus
→
AP-1_ARRE binding sites*:FOS:JUN:NFAT*@Nucleus
+ CNA*:CNB*@Nucleus
+ ERK2*@Nucleus
+ MEK1*@Nucleus
- APC@Cytoplasm
→
APC|pho@Cytoplasm