ERK1*

Protein ERK1* map

Identifiers
mitogen-activated protein kinase 3
HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.

ERK1*@Cytoplasm

References
e_re390( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.

ERK1*|​T_pho|​Y_pho|​active@Cytoplasm

References
e_re390( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
e_re394( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.

ERK1*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm

References
e_re394( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
e_re396( EMT  map ):
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase


Modifications:
In compartment: Cytoplasm
  1. ERK1*@Cytoplasm map

  2. ERK1*|​T_pho|​Y_pho|​active@Cytoplasm map
  3. ERK1*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. ERK1_2*@Cytoplasm map map ERK1*|​T_pho|​Y_pho|​active@Cytoplasm map

    2. ERK1*@Cytoplasm map map ERK1*|​T_pho|​Y_pho|​active@Cytoplasm map
    3. ERK1*|​T_pho|​Y_pho|​active@Cytoplasm map map ERK1*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map

    As Catalyser:

    1. MKNK1@Cytoplasm map + ATP@Cytoplasm map map MKNK1|​pho@Cytoplasm map + ADP@Cytoplasm map

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