EPHB2

Protein EPHB2 map

Identifiers
EPH receptor B2
“EphB2″

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:20179713
E-cadherin promotes EPHA2– ephrin-A1 localization at epithelial cell junctions
EPHA2 is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis.
EPHA2 seems to be preferentially expressed in malignant breast and prostate cancers with a basal phenotype.
EPHA1 is downregulated in advanced human skin and colorectal cancers, EphB receptors are downregulated in advanced colorectal cancer and ephrin-A5 is downregulated in glioblastomas
TNF-alpha, VEGFA and HIF2A upregulate ephrin-A1 in cultured endothelial cells.
Endothelial ephrin-B2 is upregulated by VEGF through the Notch pathway.


Modifications:
In compartment: Cytoplasm
  1. EPHB2@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. EPHB2|​pho|​hm2:​Ephrin-B1*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. EPH family*@Cytoplasm map map EPHB2@Cytoplasm map

  2. EPHB2@Cytoplasm map + Ephrin-B1*@Extracellular space map map EPHB2|​pho|​hm2:​Ephrin-B1*@Cytoplasm map

As Catalyser:

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