EPHA2:Epherin-A1*

Complex EPHA2:Epherin-A1* map


Complex composition:

  1. Epherin-A1* map
  2. EPHA2 map




EPHA2|​pho|​hm2:​Epherin-A1*@Cytoplasm

Identifiers
NAME:EPHA2:Epherin-A1*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:20179713
E-cadherin promotes EPHA2– ephrin-A1 localization at epithelial cell junctions
EPHA2 is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis.
EPHA2 seems to be preferentially expressed in malignant breast and prostate cancers with a basal phenotype.
EPHA1 is downregulated in advanced human skin and colorectal cancers, EphB receptors are downregulated in advanced colorectal cancer and ephrin-A5 is downregulated in glioblastomas
TNF-alpha, VEGFA and HIF2A upregulate ephrin-A1 in cultured endothelial cells.
Endothelial ephrin-B2 is upregulated by VEGF through the Notch pathway.
PMID:19074825
PMID:24003208
“Forward�? signaling corresponds to the proto- typical RTK mode of signaling, which is triggered by ligand binding and involves activation of the kinase domain.
However, the activation mechanisms of Eph receptors have unique features as compared to other RTK families.
Binding between Eph receptors and ephrins on juxtaposed cell surfaces leads to oligomerization through not only Eph receptor – ephrin interfaces but also receptor – receptor cis interfaces located in multiple domains
Phosphorylation of the conserved tyrosine in the activation loop appears to be less critical for Eph receptor activation than it is for many other RTKs, although it may be important for maximal activity.

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. EPHA2|​pho|​hm2:​Epherin-A1*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. EPHA2@Cytoplasm map + Epherin-A1*@Extracellular space map map EPHA2|​pho|​hm2:​Epherin-A1*@Cytoplasm map

As Catalyser:

    Leave a Reply