EGFR family*

Protein EGFR family* map

Identifiers
Receptor tyrosine kinase
epidermal growth factor receptor
“epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)” ERBB
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)
NGL “v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)”
HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
LCCS2 “lethal congenital contracture syndrome 2″
HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
“v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4″
HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910


Modifications:
In compartment: Cytoplasm
  1. EGFR family*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. EGF family*:​EGFR family*|​hm2@Cytoplasm map

  2. EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map
  3. EGFR family*|​pho|​hm2:​GRB2:​SHC1_p66_p52*|​Y_pho|​S_pho:​SOS*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map + EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map + SOS*@Cytoplasm map + GRB2@Cytoplasm map map EGFR family*|​pho|​hm2:​GRB2:​SHC1_p66_p52*|​Y_pho|​S_pho:​SOS*@Cytoplasm map

  2. EGFR family*@Cytoplasm map map EGFR@Cytoplasm map
  3. EGFR@Cytoplasm map + EGF family*@Extracellular space map + EGFR family*@Cytoplasm map map EGF family*:​EGFR family*|​hm2@Cytoplasm map
  4. EGFR family*@Cytoplasm map map HER2*@Cytoplasm map
  5. EGFR family*@Cytoplasm map map HER3*@Cytoplasm map
  6. EGFR family*@Cytoplasm map map HER4*@Cytoplasm map
  7. RTK*@Cytoplasm map map EGFR family*@Cytoplasm map
  8. EGF family*:​EGFR family*|​hm2@Cytoplasm map map EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map

As Catalyser:

  1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map map (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map

  2. GDP:​HRAS@Cytoplasm map map GTP:​HRAS@Cytoplasm map
  3. AKT1@Cytoplasm map map AKT1@Cytoplasm map
  4. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

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