EGF family*:EGFR family*

Complex EGF family*:EGFR family* map

Complex composition:

  1. EGF family* map
  2. EGFR family* map

EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm

NAME:EGF family*:EGFR family*

 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

e_re978( EMT  map ):
Autophosphorylation of PTK2:
FAK (PTK2) is first recruited to sites of integrin clustering via interactions wiith integrin-associated proteins such as talin, paxillin.
FAK binds to the cytoplasmic domain of b1 integrin via Paxillin (PXN) and Talin (TLN)
Binding to aVb3 or a5b1 integrins induces PTK2 (FAK1) autophosphorylation at Y397.
FAK associates with paxillin, vinculin, and p130cas (BCAR1) in the focal adhesion complex
Integrins control motile strategy through a Rho-cofilin pathway.
beta1 integrins promote random migration, whereas beta3 integrins promote persistent migration in the same epithelial cell background.
Adhesion to fibronectin by aVb3 supports actin cytoskeletal reorganization via cofilin, resulting in a single broad lamellipod with static cell-matrix adhesions at the leading edge.
Adhesion by a5b1 instead leads to the phosphorylation and thus inactivation of cofilin, and these cells fail to polarize their cytoskeleton but extend thin protrusions containing highly dynamic cell-matrix adhesions in multiple directions.
The activity of the small GTPase RhoA is particularly high in cells adhering by a5b1, and inhibition of Rho signaling causes a switch from a beta1 to a beta3-associated mode of migration, whereas increased Rho activity has the opposite effect.
Alterations in integrin expression profiles thus allow cells to modulate several critical aspects of the motile machinery through Rho GTPases.
e_re1275( EMT  map ):
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos


EGF family*:​EGFR family*|​hm2@Cytoplasm

NAME:EGF family*:EGFR family*

 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map


Participates in complexes:
In compartment: Cytoplasm
  1. EGF family*:​EGFR family*|​hm2@Cytoplasm map

  2. EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map + EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map + SOS*@Cytoplasm map + GRB2@Cytoplasm map map EGFR family*|​pho|​hm2:​GRB2:​SHC1_p66_p52*|​Y_pho|​S_pho:​SOS*@Cytoplasm map

  2. EGFR@Cytoplasm map + EGF family*@Extracellular space map + EGFR family*@Cytoplasm map map EGF family*:​EGFR family*|​hm2@Cytoplasm map
  3. EGF family*:​EGFR family*|​hm2@Cytoplasm map map EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map

As Catalyser:

  1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map map (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map

  2. AKT1@Cytoplasm map map AKT1@Cytoplasm map
  3. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

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