The eight members of the ephrin family are divided into distinct A and B subclasses, indicating the manner in which they are anchored to the membrane:
either by a glyco- sylphosphatidylinositol (GPI) linkage (ephrinA1-A5) or by a transmembrane domain (ephrinB1-B3).
A unique property of ephrins that is a result of membrane localization is their ability to transduce ‘‘reverse’’ signals into the cells on which they are expressed in addition to eliciting ‘‘forward’’ signaling into Eph receptor-expressing cells
Another unique aspect of ephrins that sets them apart from other RTK ligands is that their membrane- bound nature is thought to be required to elicit full Eph receptor activation.
In compartment: Extracellular space
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- Epherin family*@Extracellular space → Epherin-A1*@Extracellular space
- Epherin family*@Extracellular space → Ephrin-B1*@Extracellular space