Epherin family*

Protein Epherin family* map

Identifiers
ephrin-A1
EPLG1, TNFAIP4
HUGO:EFNA1 HGNC:3221 ENTREZ:1942 UNIPROT:P20827 GENECARDS:EFNA1 KEGG:1942 ATLASONC:GC_EFNA1 WIKI:EFNA1
ephrin-B1
EPLG2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:19074825
The eight members of the ephrin family are divided into distinct A and B subclasses, indicating the manner in which they are anchored to the membrane:
either by a glyco- sylphosphatidylinositol (GPI) linkage (ephrinA1-A5) or by a transmembrane domain (ephrinB1-B3).
A unique property of ephrins that is a result of membrane localization is their ability to transduce ‘‘reverse’’ signals into the cells on which they are expressed in addition to eliciting ‘‘forward’’ signaling into Eph receptor-expressing cells
Another unique aspect of ephrins that sets them apart from other RTK ligands is that their membrane- bound nature is thought to be required to elicit full Eph receptor activation.


Modifications:
In compartment: Extracellular space
  1. Epherin family*@Extracellular space map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Epherin family*@Extracellular space map map Epherin-A1*@Extracellular space map

    2. Epherin family*@Extracellular space map map Ephrin-B1*@Extracellular space map

    As Catalyser:

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