During EMT, tightly zipped and largely immobile epithelial cells transform into highly mobile mesenchymal cells. The extracellular matrix (ECM) including secreted molecules and basement membrane components (PMID: 21123617, PMID: 22669459, PMID: 17550969, PMID: 15316076, PMID: 12244123) plays an important role in providing cellular support, regulating both inter- and intra-cellular communication PMID: 19160017, PMID: 21132084, PMID: 16824016).
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