e_re991

Reaction known_transition_omitted e_re991 map

Actinin*@Cytoplasm map Actinin*|​pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. FAK1*|​Y_pho|​pho|​active@Cytoplasm map



References
PMID:15688067
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Confidence
REF=0 FUNC=4


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