e_re977

Reaction known_transition_omitted e_re977 map

FAK1*|​pho@Cytoplasm map FAK1*|​Y_pho|​pho|​active@Cytoplasm map

Reaction regulators:

Catalysis
  1. c-SRC*|​Y_pho|​active@Cytoplasm map



References
Autophosphorylation of PTK2:
PMID:7529872
PMID:19339212
PMID:7657702
PMID:16919435
Autophosphorylation of PTK2 at Y397 creates binding site for CSK, a member of Scr family kinases.
In response to integrin engagement with the ECM, FAK is autophosphorylated predominantly on Y397
This Y397 is the consensus binding site for the SH2 domain of c-Src (CSK)
PMID:11114741
Interaction of CSK with FAK leads to phosphorylation of FAK on other tyrosine residues including Y407, 576, 577, 861, 925/
These phosphorylation events promote PTK2 to its maximal catalytic activity.
Upon autophosphorylation of FAK, a signaling complex of FAK, CSK binds to and can phosphorylate various adaptor proteins such as p130Cas and paxillin.

Confidence
REF=3 FUNC=5


Leave a Reply