e_re964

Reaction heterodimer_association e_re964 map

PAK1@Cytoplasm map + NISCH@Nucleus map NISCH:​PAK1@Cytoplasm map

Reaction regulators:

Physical_stimulation
  1. GTP:​RAC1@Cytoplasm map



References
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.

Confidence
REF=2 FUNC=4


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