e_re909

Reaction heterodimer_association e_re909 map

Fibronectin*@Extracellular space map + a5b1*_aVb3*@Extracellular space map Fibronectin*:​a5b1*_aVb3*@Extracellular space map

No reaction regulators

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
PMID:15866889
Fibronectin binds to alphaV/beta3 integrins supports persistent migration( directional cell migration)
Fibronectin binds to alpha5/beta1 integrins supports random migration.

Confidence
REF=5 FUNC=5


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