e_re802

Reaction state_transition e_re802 map

WASF1@Cytoplasm map WASF1@Cytoplasm map

Reaction regulators:

Catalysis
  1. BNIP2@Cytoplasm map
Inhibition
  1. CYFIP2@Cytoplasm map
  2. NCKAP1@Cytoplasm map



References
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin

Confidence
REF=3 FUNC=4


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