e_re788

Reaction state_transition e_re788 map

BAIAP2@Cytoplasm map BAIAP2@Cytoplasm map

Reaction regulators:

Physical_stimulation
  1. GTP:​RAC1@Cytoplasm map



References
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane rufflin
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.

Confidence
REF=3 FUNC=5


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