e_re786

Reaction negative_influence e_re786 map

GTP:​RAC1@Cytoplasm map CYFIP2@Cytoplasm map

No reaction regulators

References
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin

Confidence
REF=1 FUNC=5


Leave a Reply