e_re474

Reaction state_transition e_re474 map

Occludin*@Cytoplasm map + ATP@Cytoplasm map Occludin*|​pho@Cytoplasm map + ADP@Cytoplasm map

Reaction regulators:

Catalysis
  1. v-SRC*@Cytoplasm map



References
PMID:22315516
-Occludin is phosphorylated at S340 by PKC
-Occludin is phosphorylated at T383 and S508 by ROCK
-Occludin is phosphorylated at Y398, Y402 and Y474 by SRC
-Occludin is phosphorylated at T400, T404 and S408 by CK2
-Occludin is phosphorylated at S403 and S404 by PKC-N
-Occludin is phosphorylated at T424 and T438 by PKC-E
-Occludin is phosphorylated at S490 by VEGF
PMID:19017651
PMID:12604349
In mouse, phosphorylation of Occludin by SRC (at Y398, Y402) reduces TIGHT_JUNCTIONS assembly
In mouse, phosphorylation of Occludin by SRC (at Y398, Y402) reduces interaction between Occludin and ZO1,2,3
PMID:20152177
In mouse, phosphorylation of Occludin by SRC (at Y474) increases interaction between Occludin and PI3K
In mouse, phosphorylation of Occludin by SRC (at Y474) increases wound healing and migration
PMID:12547828
Inactive Src delays the oxidative stress-induced disruption of tight junction and accelerates calcium- induced assembly of tight junction in Caco-2 cells.
This demonstrates that oxidative stress-induced disruption of tight junction is mediated by the activation of Src.

Confidence
REF=4 FUNC=4


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