e_re472

Reaction known_transition_omitted e_re472 map

LIMK1@Cytoplasm map LIMK1|​pho|​active@Nucleus map

Reaction regulators:

Catalysis
  1. PAK1@Cytoplasm map
  2. CDC42BPA@Cytoplasm map
  3. PAK4@Cytoplasm map
  4. ROCK*|​active|​open@Cytoplasm map



References
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:11018042
LIMK1 is regulated by Pak1,

Confidence
REF=5 FUNC=4


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