e_re466

Reaction heterodimer_association e_re466 map

AXIN1@Cytoplasm map + DVL1:​FZD*:​LRP5_6*:​WNT*@Cytoplasm map + FRAT1@Cytoplasm map AXIN1:​DVL1:​FRAT1@Cytoplasm map

No reaction regulators

References
PMID:10428961
PMID:8666229
Wnt transduces their signals through DVL1 to inhibit GSK3B, leading to the accumulation of cytosolic CTNNB1 and activation of TCF/LEF1 transcription factors.
DVL1 interacts with AXIN1 and with Frat1.
Binding of AXIN1 to DVL1 reduces formation of the destruction complex APC/AXIN1.

Confidence
REF=2 FUNC=3


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