e_re463

Reaction known_transition_omitted e_re463 map

APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map → degraded

No reaction regulators

References
PMID:19751508
PMID:22270359
PMID:16940750
in the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
Upon ligand binding (right panel), DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs

Confidence
REF=2 FUNC=5


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