e_re437

Reaction heterodimer_association e_re437 map

p53*@Mitochondria map + BAK1@Mitochondria map BAK1:​p53*@Mitochondria map

No reaction regulators

References
PMID:15077116
p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53–Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.

Confidence
REF=1 FUNC=5


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