e_re433

Reaction heterodimer_association e_re433 map

p53*@Mitochondria map + BCL2@Mitochondria map BCL2:​p53*@Mitochondria map

No reaction regulators

References
PMID:12667443
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.

Confidence
REF=1 FUNC=5


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