e_re397

Reaction state_transition e_re397 map

MKNK2@Cytoplasm map + ATP@Cytoplasm map MKNK2|​pho@Cytoplasm map + ADP@Cytoplasm map

Reaction regulators:

Catalysis
  1. ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map



References
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

Confidence
REF=3 FUNC=5


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