e_re388

Reaction state_transition e_re388 map

MEK1*@Cytoplasm map + ATP@Cytoplasm map MEK1*|​S218_pho|​S222_pho|​active@Cytoplasm map + ADP@Cytoplasm map

Reaction regulators:

Catalysis
  1. RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​S338_pho|​active|​open@Cytoplasm map



References
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.

Confidence
REF=1 FUNC=5


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