Reaction state_transition e_re388
MEK1*@Cytoplasm + ATP@Cytoplasm
→ MEK1*|S218_pho|S222_pho|active@Cytoplasm
+ ADP@Cytoplasm
Reaction regulators:
References
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
Confidence REF=1 FUNC=5