Reaction state_transition e_re388

MEK1*@Cytoplasm + ATP@Cytoplasm → MEK1*|​S218_pho|​S222_pho|​active@Cytoplasm + ADP@Cytoplasm

Reaction regulators:

Catalysis

1. RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​S338_pho|​active|​open@Cytoplasm

References
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.

Confidence
REF=1 FUNC=5