e_re383

Reaction state_transition e_re383 map

RAF1|​closed@Cytoplasm map + ATP@Cytoplasm map RAF1|​S_pho|​closed@Cytoplasm map + ADP@Cytoplasm map

Reaction regulators:

Catalysis
  1. ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytoplasm map



References
Negative feedback: MAPK1/ERK2 phosphorylates RAF1 on Ser 29, 43, 289, 296, 301, 642, generating an inactive kinase.
PIN1, a prolyl isomerase converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A.

Confidence
REF=0 FUNC=5


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