Reaction heterodimer_association e_re342
Occludin*:PARD6A:TGFBR1|hm2@Cytoplasm + TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytoplasm → Occludin*:PARD6A:TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytoplasm
No reaction regulators
Occludin is a structural component of tight junctions that is associated with the cell polarity network.
Occludin regulates TGFBR1 localization for efficient TGFB-dependent dissolution of tight junctions during EMT
Interaction of endogenous OCLN with endogenous TGFBR1 was not modulated by TGFB
but its association with the TGFBR2 increased in a TGFB-dependent manner
TGFBR1 localizes with ZO-1 on the cellular apical aspect together with PARD6A and they are situated apically to endogenous E-cadherin
After stimulation by TGFB, TGFBR2 is redistributed to the tight junctions, where it localizes with both TGFBR1 and ZO-1.