Reaction state_transition e_re341 
Occludin*:PARD6A:TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytoplasm + ATP@Cytoplasm → Occludin*:PARD6A|S345_pho:TGFB1|hm2:TGFBR1|Ser_pho|hm2:TGFBR2|Ser_pho|hm2@Cytoplasm + ADP@Cytoplasm
Reaction regulators:
Maps_Modules
EMT / EMT_REGULATORS
EMT / CELL_CELL_ADHESIONS
EMT / TIGHT_JUNCTIONS
References
PMID:15761148
After stimulation by TGFB, TGFBR2 is redistributed to the tight junctions, where it localizes with both TGFBR1 and ZO-1.
Active TGFBR2 recruited to TIGHT_JUNCTIONS phosphorylates PARD6A on Serine residue S345 and it also phosphorylates TGFBR1
Once phosphorylated by TGFBR2, both TGFBR1 and PARD6A become active
Confidence
REF=1 FUNC=4