e_re1616

Reaction transport e_re1616 map

RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​S338_pho|​active|​open@Cytoplasm map RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​S338_pho|​active|​open@Mitochondria map

No reaction regulators

References
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

Confidence
REF=1 FUNC=0


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