Reaction heterodimer_association e_re1275
SHC1_p66_p52*|Y_pho|S_pho|active@Cytoplasm + EGF family*:EGFR family*|pho|hm2@Cytoplasm + SOS*@Cytoplasm + GRB2@Cytoplasm → EGFR family*|pho|hm2:GRB2:SHC1_p66_p52*|Y_pho|S_pho:SOS*@Cytoplasm
No reaction regulators
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos