e_re1247

Reaction transcription e_re1247 map

gID2@Nucleus map rID2@Nucleus map

Reaction regulators:

Inhibition
  1. TGFB1|​hm2|​active@Extracellular space map
Physical_stimulation
  1. HIF1B*:​HIF_alpha_*@Nucleus map
  2. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map



References
PMID:11708773
PMID:15252039
ID2 is target of HIF1 upon hypoxic conditions
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)

Confidence
REF=5 FUNC=4


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