Reaction state_transition e_re122
TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytoplasm + ATP@Extracellular space → TGFB1|hm2:TGFBR1|Ser_pho|hm2:TGFBR2|Ser_pho|hm2@Cytoplasm + ADP@Extracellular space
The active ligand–receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2 autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.