e_re122

Reaction state_transition e_re122 map

TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytoplasm map + ATP@Extracellular space map TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytoplasm map + ADP@Extracellular space map

Reaction regulators:

Catalysis
  1. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytoplasm map



Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:12809600
PMID:22710166
The active ligand–receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2 autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.

Confidence
REF=0 FUNC=5


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