Reaction known_transition_omitted e_re1217
MDM2|S186_pho:SNAI2:p53*@Nucleus → degraded
No reaction regulators
Phosphorylations on p53 prevent its binding to MDM2.
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
Complex of p53, MDM2 and Slug faciliates the proteasomal degradation of Slug by MDM2.