e_re1217

Reaction known_transition_omitted e_re1217 map

MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map → degraded

No reaction regulators

References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:19448627
Complex of p53, MDM2 and Slug faciliates the proteasomal degradation of Slug by MDM2.

Confidence
REF=3 FUNC=5


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