e_re1186

Reaction known_transition_omitted e_re1186 map

TWIST1@Nucleus map TWIST1|​S68_pho@Nucleus map

Reaction regulators:

Unknown_catalysis
  1. p38*@Nucleus map
  2. JNK*@Nucleus map
  3. ERK1_2*@Nucleus map



References
PMID:21502402
Phosphorylation of serine 68 of Twist1 stabilizes Twist1 protein and promotes breast cancer cell invasiveness.
Twist1 can be phosphorylated in vitro at Serin 68 by MAPKs (p38MAPKs, JNKs, ERK1/2)
This phosphorylation is required for Twist1 protein stability.
pSer 68 stabilizes Twist1 by protecting Twist1 from ubiquitination
Ser 68 phosphorylation is required for Twist1- promoted EMT and breast cancer cell invasion

Confidence
REF=1 FUNC=4


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