Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.
Role of TGFB in regulation of cell cycle:
Physiologically, TGFB is a potent inhibitor of cell cycle.
It induces expression of p15INK4B and represses expression of c-Myc
Low levels of c-Myc allows TGFB to induce p15INK4B and p21CIP1 transcription