e_re1123

Reaction transcription e_re1123 map

gMYC@Nucleus map rMYC@Nucleus map

Reaction regulators:

Physical_stimulation
  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  2. STAT3|​pho|​active@Nucleus map



References
PMID:15810077
Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.
PMID:22943793
Role of TGFB in regulation of cell cycle:
Physiologically, TGFB is a potent inhibitor of cell cycle.
It induces expression of p15INK4B and represses expression of c-Myc
Low levels of c-Myc allows TGFB to induce p15INK4B and p21CIP1 transcription

Confidence
REF=1 FUNC=4


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