Reaction heterodimer_association e_re1006
VE-Cadherin*@Cytoplasm + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm → VE-Cadherin*:_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm
No reaction regulators
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
VE-cadhein interacts with Plakoglobin (JUP)