e_re1006

Reaction heterodimer_association e_re1006 map

VE-Cadherin*@Cytoplasm map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

No reaction regulators

References
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

Confidence
REF=3 FUNC=5


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