E1*

Protein E1* map

Identifiers
ubiquitin-like modifier activating enzyme 1
HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1
ubiquitin-like modifier activating enzyme 2
HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2
ubiquitin-like modifier activating enzyme 5
HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5
ubiquitin-like modifier activating enzyme 6
HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6
ubiquitin-like modifier activating enzyme 7
HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7
ubiquitin-like modifier activating enzyme 3
HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3
ENREZ:79876
POC20 “POC20 centriolar protein homolog (Chlamydomonas)” “UBA1 ubiquitin-activating enzyme E1 homolog (yeast)” UBE1X

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:15340381
PMID:12820959
PMID:19352404
SAE1/SAE2

E1*@Cytoplasm

References
s_shh1_re92:( Survival  map ) PMID:18997815

E1*@Nucleus

References
s_akt2_re39:( Survival  map ) PMID:15147722 PMID:18006823
s_akt2_re46:( Survival  map ) PMID:15531880
s_akt2_re68:( Survival  map ) PMID:15169778 PMID:10722742
s_akt2_re70( Survival  map ):
PMID:10721693
PMID:19459846
s_akt2_re149:( Survival  map ) PMID:19440234
s_wca3_re32:( Survival  map ) PMID:16714285
s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a “?”. Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
s_wnc3_re18( Survival  map ):
Order of sumoylation is not important.
PMID:19218564

E1*@Nucleus

References
s_wca3_re151:( Survival  map ) PMID:22322943


Modifications:
In compartment: Cytoplasm
  1. E1*@Cytoplasm map

  2. E1*@Cytoplasm map
  3. E1*@Cytoplasm map
  4. E1*@Cytoplasm map
  5. E1*@Cytoplasm map

In compartment: Nucleus

  1. E1*@Nucleus map

  2. E1*@Nucleus map
  3. E1*@Nucleus map
  4. E1*@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map

  2. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. E1*@Cytoplasm map + RAD6*@Cytoplasm map + NEDD8@Cytoplasm map + s_s_wca1_s1717 + FAF*@Cytoplasm map map E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map

  2. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map + CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  3. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map map CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​NEDD8:​PKD*:​RAD6*:​SKP*:​USP15@Cytoplasm map + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map

As Catalyser:

  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map map Ubiquitination@Cytoplasm map

  2. GF:​RTK*|​pho|​pho|​hm2@Endosome map map Ubiquitination@Cytoplasm map
  3. PHLPP*|​S869_pho|​S847_pho@Cytoplasm map map PHLPP*|​S869_pho|​S847_pho|​ubi|​ubi@Cytoplasm map
  4. HERC1:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  5. PAM*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  6. E3*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  7. CUL4*:​DCAF*:​FBW5*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  8. MTOR@Cytoplasm map map MTOR|​Y631_ubi@Cytoplasm map
  9. PDCD4|​S67_pho@Cytoplasm map map PDCD4|​S67_pho|​ubi@Cytoplasm map
  10. FOXO3|​S644_pho@Cytoplasm map map FOXO3|​S644_pho|​ubi@Cytoplasm map
  11. s_s_akt2_s384 map s_s_akt2_s399
  12. p27KIP1*|​pho@Nucleus map map p27KIP1*|​pho|​pho@Nucleus map
  13. p27KIP1*|​pho@Cytoplasm map map p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm map
  14. MDM2|​pho|​pho@Nucleus map map MDM2|​pho|​pho|​ubi@Nucleus map
  15. p53*@Nucleus map map p53*|​ubi@Nucleus map
  16. FOXO3|​pho|​pho|​pho@Cytoplasm map map FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm map
  17. p53*@Nucleus map map p53*|​ubi|​ubi@Nucleus map
  18. FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map map FOXO1|​T24_pho|​S322_ubi|​S256_pho|​S319_pho@Cytoplasm map
  19. GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytoplasm map map GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho|​ubi|​ubi|​ubi|​ubi:​SUFU:​ULK3@Cytoplasm map
  20. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytoplasm map map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytoplasm map
  21. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytoplasm map map GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytoplasm map
  22. GLI1@Cytoplasm map map GLI1|​ubi|​ubi@Cytoplasm map
  23. SUFU@Cytoplasm map map SUFU|​K257_ubi@Cytoplasm map
  24. GLI3-190*|​unk|​active@Nucleus map map GLI3-190*|​ubi|​ubi|​ubi|​ubi@Nucleus map
  25. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus map map GLI2-185*|​ubi|​ubi|​pho|​unk|​S956_emp|​active@Nucleus map
  26. HDAC1@Nucleus map map HDAC1|​ubi|​ubi@Nucleus map
  27. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map + CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  28. AXIN2@Nucleus map map AXIN2|​ubi@Nucleus map
  29. LEF_TCF*|​S166_pho|​T155_pho@Nucleus map map LEF_TCF*|​S166_pho|​T155_pho|​ubi@Nucleus map
  30. s_s_wnc2_s333 map PPP3CB|​ubi|​ubi|​ubi:​PPP3R*@Cytoplasm map
  31. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map
  32. NFAT1*@Nucleus map map NFAT1*|​unk@Nucleus map
  33. NFAT1*|​unk@Nucleus map map NFAT1*|​unk|​unk@Nucleus map
  34. NFAT2*@Nucleus map map NFAT2*|​K702_unk|​K914_unk@Nucleus map

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